Calcium Channel Blockers(Nifedipine) Taking During Pregnancy

Calcium channel blockers (CCBs) are a highly prescribed class of drugs used for the treatment of angina pectoris, hypertension, and cardiac arrhythmias. These vasodilating agents relax smooth muscle by inhibiting the entry of calcium into muscles or by inhibiting its release from intracellular storages. This relaxation in blood vessel walls results in dilation of arteries and, subsequently, in reduction of blood pressure (Ducsay et al., 1987).

Nifedipine is a calcium channel blocker medicine that slows smooth muscle function. Muscles need calcium to function properly, and a calcium channel blocker interferes with the supply of calcium to the muscle. This allows the smooth muscle wall of the blood vessels to relax and widen, reducing blood pressure.

Nifedipine was given a pregnancy Category C rating because of potential problems in animal studies. When given to pregnant rabbits, mice, and rats, nifedipine caused increased miscarriages and birth defects. These birth defects included problems with fingers or toes, rib deformities, and cleft palate.

However, it is important to note that animals do not always respond to medicines the same way that humans do. Therefore, a pregnancy Category C medicine may be given to a pregnant woman if her healthcare provider believes that the benefits to the woman outweigh any risks to the unborn child.

Nifedipine is sometimes used to stop preterm labor, especially when other medications have failed. It helps to relax the smooth muscle of the uterus, stopping premature labor. Since nifedipine is not approved for preterm labor, however, this is considered an "off-label" use.

If you are pregnant or are thinking of becoming pregnant while taking nifedipine, let your healthcare provider know. He or she will consider both the benefits and risks of using nifedipine during pregnancy before making a recommendation in your particular situation.

Sourceshttp://health.msn.com/pregnancy/nifedipine-for-high-blood-pressure-during-pregnancy
http://www.fetal-exposure.org/resources/index.php/1996/09/01/calcium-channel-blockers-and-pregnancy/
http://blood-pressure.emedtv.com/nifedipine/nifedipine-and-pregnancy-p2.html

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Ditulis oleh: Unknown - Saturday, 29 October 2011