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POTASSIUM CITRATE Indication Doses Contra Indications and Adverse Effects

Indications:

Urinary alkalinizer, when Na Citrate is contraindicated, prevention of uric acid nephrolithiasis and calcium renal stones.

Doses & Administrations:
Administration *dilute adequately with water to minimize gastrointestinal injury * take after meals to avoid saline laxative effect * palatability of oral solution enhanced by chilling ADULT DOSE: FOR URIC ACID STONE: 30 to 60 milliequivalents/day orally in three or four doses with meals or within 30 minutes after meals. ............Mix in 10-30 ml of water or juice................... Maximum daily dosage is 100 milliequivalents PEDIATRIC DOSE: 5-10 mEq after meals and at bed time. NOTE: 1 gm Potassium Citrate = 3.08 mMoles (9.25mEq) Citrate 9.03 mMoles (9.03mEq) potassium

Contra Indications:
Addison's disease, untreated adynamia episodica hereditaria anuria, dehydration, acute heat cramps, hyperkalemia myocardial damage, severe renal impairment with oliguria or azotemia

Precautions:
Monitor serum electrolytes, especially bicarbonate, in patients with renal disease Potassium citrate in patients with decreased urinary output, especially in the presence of hypocalcemia

Pregnancy Status:
CATEGORY "C"

Renal Failure Doses:
CONTRAINDICATED in severe renal impairment, oligouria and azotemia.
Lactation Status:
SAFE

Interactions:
k-SPARING DIURETICS It may cause an increase in toxicity of following drugs: quinine, quinidine, amphetamines, ephedrine. It decreases effectiveness of: lithium, MTX, and tetracyclines.

Adverse Effects:
SERIOUS: alkalosis electrocardiographic abnormalities (associated with hyperkalemia) hyperkalemia

Nursing Considerations:
Use well diluted, chilled solution.Use the solution with in 1 hour of preparation. Watch patient for signs of hyperkalemia, and check bicarbonate levels periodically. Do not administer on an empty stomach.
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Ditulis oleh: Unknown - Monday, 13 June 2011