Pharmacologicalaction
Suxamethonium chloride is a deplorising neuromuscular blocking agent.the initial effect is to depolarize the membrane in the same manner as acetylcholine,but more peristently,ehich results in a brief period of firing manifested by transient muscular fasciculation.This phase is succeeded shortly by neuromuscular paralysis
the mechanism and even the primary site of which are still uncertain and controversial.
Indication
Suxamethonium (Cl) is primarily indicated in conditions like Muscle relaxation (rapid onset, short duration), Muscular spasm, Neuromuscular blockade, and can also be given in adjunctive therapy as an alternative drug of choice in Anesthesia, Insomnia, Surgery.
Side Effect of suxamethonium chloride
Warnings / Precautions
Avoid suxamethazone in patients with burns, massive trauma, renal impairment, severe long lasting sepsis and severe hyperkalaemia, sensitivity to drug, eye injury or glaucoma. It should be used with caution in patients with bone fractures, cardiac or respiratory disease. Dose of neuromuscular blocking agent need to be clearly titrated for individual patients according to their response; monitoring of the degree of block is recommended in order to reduce the risk of overdosage. Patients who have received neuromuscular blocker should always have their respiration assisted or controlled until the drug has been inactivated or antagonized.
Dosage of suxamethonium chloride
Determined by the physician according to patient's needs.
Usual dose: 20 to 80 mg intravenously maximum up to 100mg.2.5mg to 4mg per kg body weight intramuscularly maximum up to 150mg
Suxamethonium chloride is a deplorising neuromuscular blocking agent.the initial effect is to depolarize the membrane in the same manner as acetylcholine,but more peristently,ehich results in a brief period of firing manifested by transient muscular fasciculation.This phase is succeeded shortly by neuromuscular paralysis
the mechanism and even the primary site of which are still uncertain and controversial.
Indication
Suxamethonium (Cl) is primarily indicated in conditions like Muscle relaxation (rapid onset, short duration), Muscular spasm, Neuromuscular blockade, and can also be given in adjunctive therapy as an alternative drug of choice in Anesthesia, Insomnia, Surgery.
Side Effect of suxamethonium chloride
- Increased saliva levels or mucous
- production
- Rash
- Muscle twitching or pain
- Flushing
- Itching
- More bowel movements than
- normal
- Change in heart beat or
- palpitations
- Eye pain
- Muscle stiffness
- Fever
- Breathing difficulties, rash or
- Irritation
- Headache
- Feeling faint
Warnings / Precautions
Avoid suxamethazone in patients with burns, massive trauma, renal impairment, severe long lasting sepsis and severe hyperkalaemia, sensitivity to drug, eye injury or glaucoma. It should be used with caution in patients with bone fractures, cardiac or respiratory disease. Dose of neuromuscular blocking agent need to be clearly titrated for individual patients according to their response; monitoring of the degree of block is recommended in order to reduce the risk of overdosage. Patients who have received neuromuscular blocker should always have their respiration assisted or controlled until the drug has been inactivated or antagonized.
Dosage of suxamethonium chloride
Determined by the physician according to patient's needs.
Usual dose: 20 to 80 mg intravenously maximum up to 100mg.2.5mg to 4mg per kg body weight intramuscularly maximum up to 150mg
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Ditulis oleh:
Unknown - Sunday, 22 May 2011
