Indications:
Levofloxacin is the active stereisomere of ofloxacin. Levofloxacin is approved for the treatment of COMMUNITY ACQUIRED PNEUMONIA,and other repiratory tract infections.
Doses & Administrations:
ADULTS: RTI: 500 mg ONCE DAILY TB : 500 mg bid or 750 mg qd May take with or with out meals. Take at least 2 hours apart from antacids, zinc and iron containing preps. PEDIATRIC (IV+PO) : Limited data for dose available. 5-10mg/kg/day, maximum : 500 mg/day
Contra Indications:
Hypersensitivity to levofloxacin,other fluoroquinolones, or to any of its components.
Precautions:
CNS disorders (epilepsy) Renal insufficiency (dose reduction) Liver disease (transamine elevations have occured) Risk factors for tendinitis include pt.>60 years of age,renal failure, dialysis,concomitant therapy,and dyslipidemia. Pregnant and nursing women.
Pregnancy Status:
Category "C"
Renal Failure Doses:
Cr.clear(ml/min) Loading Dose Subsequent dose =======20-49 500 mg 250 mg/24 hr. 10-19 500 mg 250 mg/48 hr. Hemodialysis 500 mg 250 mg/48 hr. (<10ml/min) NOTE: No need to give loading dose if pt. is already on Levofloxacin.
Lactation Status:
Unknown,levofloxacin has not been measured in human milk, however, based upon data from ofloxacin,it can be presumed that it will be excreted.
Interactions:
Minor and moderate interactions with drugs like antacids,calcium , cimetidine are reported with levofloxacin. DRUG FOOD INTERACTIONS: *Take atleast 02hrs before or after antacids,dairy products,sucralfate,iron supplements,calcium,magnesium,aluminium,zinc,minerals & multivitamins. * Limit fat & caffeine intake REF: http://www.mdanderson.org/departments/nutrition/index.cfm
Adverse Effects:
The most common adverse effects are nausea,diarrhea,headache,and constipation. Levofloxacin should be avoided in prepubertal children since animal studies have demonstrated erosion of the cartilage and weight-bearing joints.
Nursing Considerations:
THE VIAL IS FOR SINGLE USE ONLY. The diluted solution in compatible fluids is stable for 14 days in refrigerator and 72 hours at room temperature at the concentration of 5mg/ml in plastic IV containers.
Levofloxacin is the active stereisomere of ofloxacin. Levofloxacin is approved for the treatment of COMMUNITY ACQUIRED PNEUMONIA,and other repiratory tract infections.
Doses & Administrations:
ADULTS: RTI: 500 mg ONCE DAILY TB : 500 mg bid or 750 mg qd May take with or with out meals. Take at least 2 hours apart from antacids, zinc and iron containing preps. PEDIATRIC (IV+PO) : Limited data for dose available. 5-10mg/kg/day, maximum : 500 mg/day
Contra Indications:
Hypersensitivity to levofloxacin,other fluoroquinolones, or to any of its components.
Precautions:
CNS disorders (epilepsy) Renal insufficiency (dose reduction) Liver disease (transamine elevations have occured) Risk factors for tendinitis include pt.>60 years of age,renal failure, dialysis,concomitant therapy,and dyslipidemia. Pregnant and nursing women.
Pregnancy Status:
Category "C"
Renal Failure Doses:
Cr.clear(ml/min) Loading Dose Subsequent dose =======20-49 500 mg 250 mg/24 hr. 10-19 500 mg 250 mg/48 hr. Hemodialysis 500 mg 250 mg/48 hr. (<10ml/min) NOTE: No need to give loading dose if pt. is already on Levofloxacin.
Lactation Status:
Unknown,levofloxacin has not been measured in human milk, however, based upon data from ofloxacin,it can be presumed that it will be excreted.
Interactions:
Minor and moderate interactions with drugs like antacids,calcium , cimetidine are reported with levofloxacin. DRUG FOOD INTERACTIONS: *Take atleast 02hrs before or after antacids,dairy products,sucralfate,iron supplements,calcium,magnesium,aluminium,zinc,minerals & multivitamins. * Limit fat & caffeine intake REF: http://www.mdanderson.org/departments/nutrition/index.cfm
Adverse Effects:
The most common adverse effects are nausea,diarrhea,headache,and constipation. Levofloxacin should be avoided in prepubertal children since animal studies have demonstrated erosion of the cartilage and weight-bearing joints.
Nursing Considerations:
THE VIAL IS FOR SINGLE USE ONLY. The diluted solution in compatible fluids is stable for 14 days in refrigerator and 72 hours at room temperature at the concentration of 5mg/ml in plastic IV containers.
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Ditulis oleh:
Unknown - Sunday, 29 May 2011
