This XIII factor deficiency can raise the problems of re-bleeding by incorrect cross-linking of fibrin, which helps in blood clotting. This bleeding is the same like hemophilia. This is why, factor XIII deficiency is also called as fibrin stabilizing factor deficiency. This is the rarest of all the factor deficiencies that are known. Like others, this is also an inherited autosomal recessive deficiency that means both men and women are affected equally.
There are two different sex chromosomes named X and Y. A female gets one X chromosome from the mother and another X chromosome from the father (XX). A male gets an X chromosome from the mother and Y chromosome from the father (XY). The gene causing hemophilia is present on the X chromosome.
A child with hemophilia generally has various other male relatives suffering from hemophilia. Many times, babies are born with hemophilia in a family that has no trait of hemophilia. This happens when the gene is “hidden”, this means that the gene is transferred but does not affect the male offspring. After years and years, it becomes active and the person gets infected. A baby can be infected in many ways. The possibilities for infections are: a non carrier girl, a disease carrier girl, boy infected with hemophilia, boy non-infected with hemophilia. A pregnant woman who is infected with the disease has only twenty-five% chances of having an infected son. The father’s X chromosome tells that there will be a girl child, so every daughter of a hemophilic infected man will be the carrier of the disease. The sons are not hemophilic. A proper genetic counseling helps a lot to avoid such diseases.
Symptoms of Factor XIII Deficiencies
Factor XIII is a deficiency, which is rare that happens when there is deficiency of fibrin. The main symptom of all factor deficiencies is bleeding. However, the way of bleeding differs. Some of the symptoms are described as follows:
Factor XIII deficiency can be treated like other factor deficiencies. Some of the options are frozen plasma. Other option for this is genetic replacement of the faulty gene on X chromosome. Abnormal blood clotting should not be taken normally as this becomes severe as time passes. This situation can be fatal as well because a person can have severe unstoppable bleeding if he undergoes surgery. A proper genetic counseling will help a lot to avoid such problems in child if parents are affected by factor XIII.
There are two different sex chromosomes named X and Y. A female gets one X chromosome from the mother and another X chromosome from the father (XX). A male gets an X chromosome from the mother and Y chromosome from the father (XY). The gene causing hemophilia is present on the X chromosome.
A child with hemophilia generally has various other male relatives suffering from hemophilia. Many times, babies are born with hemophilia in a family that has no trait of hemophilia. This happens when the gene is “hidden”, this means that the gene is transferred but does not affect the male offspring. After years and years, it becomes active and the person gets infected. A baby can be infected in many ways. The possibilities for infections are: a non carrier girl, a disease carrier girl, boy infected with hemophilia, boy non-infected with hemophilia. A pregnant woman who is infected with the disease has only twenty-five% chances of having an infected son. The father’s X chromosome tells that there will be a girl child, so every daughter of a hemophilic infected man will be the carrier of the disease. The sons are not hemophilic. A proper genetic counseling helps a lot to avoid such diseases.
Symptoms of Factor XIII Deficiencies
Factor XIII is a deficiency, which is rare that happens when there is deficiency of fibrin. The main symptom of all factor deficiencies is bleeding. However, the way of bleeding differs. Some of the symptoms are described as follows:
- Bleeding is unstable due to the absence of factor XIII in the body. Severe bleeding can lead to trauma.
- As the fibrin is not placed perfectly, a person can have re-bleeding problems. Re-bleeding can pose a problem for a person with internal injury, especially injury to head
- If any woman suffers from this disease and if it goes untreated, then they can face problems during pregnancy. Either they have severe bleeding after pregnancy or even they can have abortion due to severe internal bleeding in the first trimester of pregnancy itself.
- Men with Factor XIII deficiency can face problems of infertility.
- Some of the other common problems that are seen in every person suffering from this disease are joint bleeding, soft tissue bleeds, menorrhagia, and constant bleeding through circumcision or at the place of the umbilical cord.
- A woman with this disease can have improper menstrual cycle.
Factor XIII deficiency can be treated like other factor deficiencies. Some of the options are frozen plasma. Other option for this is genetic replacement of the faulty gene on X chromosome. Abnormal blood clotting should not be taken normally as this becomes severe as time passes. This situation can be fatal as well because a person can have severe unstoppable bleeding if he undergoes surgery. A proper genetic counseling will help a lot to avoid such problems in child if parents are affected by factor XIII.
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Unknown - Tuesday, 26 April 2011
