Imipenem and cilastatin combination is used to treat infections in many different parts of the body. nfections caused by bacteria. It is sometimes given with other antibiotics.
PRECAUTIONS: Before using imipenem with cilastatin, tell your doctor or pharmacist if you are allergic to either of its ingredients; or to penicillins or cephalosporins; or if you have any other allergies.Before using this medication, tell your doctor or pharmacist your medical history, especially of: brain disorders (e.g., seizures, head injury, tumor), kidney disease, liver disease, stomach/intestinal diseases (e.g., colitis).Kidney function declines as you grow older. This medication is removed by the kidneys. Therefore, elderly people may be at greater risk for side effects while using this drug.During pregnancy, this medication should be used only when clearly needed. Discuss the risks and benefits with your doctor.This medication passes into breast milk. Though there have been no reports of harm to nursing infants, consult your doctor before breast-feeding.
Dosage and Administration
Adults
IV 125, 250, or 500 mg dose over 20 to 30 min. Infuse a 750 mg or 1 g dose over 40 to 60 min. If nausea develops, slow the infusion rate. Max: 50 mg/kg/day or 4 g/day, whichever is lower.
Adults
IM 500 to 750 mg every 12 h. Max: 1,500 mg/day.
Children less than 40 kg
IM 60 mg/kg/day.
Children at least 40 kg
IM Adult dose.
Premature Infants (at least 36 wk Gestational Age)
IM 20 mg/kg every 12 h.
General Advice
For IV administration, reconstitute with 100 mL of compatible diluent. Shake until suspension is clear; add suspension to 100 mL of appropriate infusion solution. Then add 10 mL of infusion to vial; shake well to ensure that all medication is used and transfer resulting suspension to infusion solution. Color of solution may range from colorless to yellow. Solution is stable for 4 h at room temperature and for 24 h when refrigerated. Do not administer if solution is cloudy.
Do not mix with or physically add to antibiotics. However, it may be administered concomitantly with other antibiotics (eg, aminoglycosides).
Do not use IM preparation for IV administration.
For IM administration, prepare with 1% lidocaine HCl solution (without epinephrine). Prepare 500 mg vial with 2 mL and 750 mg vial with 3 mL of lidocaine. Agitate to form suspension. Color of solution may range from white to light tan. Withdraw and inject entire contents of vial IM. Use within 1 h of preparation.
Storage/Stability
Store unreconstituted powder at or below 77°F.
PRECAUTIONS: Before using imipenem with cilastatin, tell your doctor or pharmacist if you are allergic to either of its ingredients; or to penicillins or cephalosporins; or if you have any other allergies.Before using this medication, tell your doctor or pharmacist your medical history, especially of: brain disorders (e.g., seizures, head injury, tumor), kidney disease, liver disease, stomach/intestinal diseases (e.g., colitis).Kidney function declines as you grow older. This medication is removed by the kidneys. Therefore, elderly people may be at greater risk for side effects while using this drug.During pregnancy, this medication should be used only when clearly needed. Discuss the risks and benefits with your doctor.This medication passes into breast milk. Though there have been no reports of harm to nursing infants, consult your doctor before breast-feeding.
Dosage and Administration
Adults
IV 125, 250, or 500 mg dose over 20 to 30 min. Infuse a 750 mg or 1 g dose over 40 to 60 min. If nausea develops, slow the infusion rate. Max: 50 mg/kg/day or 4 g/day, whichever is lower.
Adults
IM 500 to 750 mg every 12 h. Max: 1,500 mg/day.
Children less than 40 kg
IM 60 mg/kg/day.
Children at least 40 kg
IM Adult dose.
Premature Infants (at least 36 wk Gestational Age)
IM 20 mg/kg every 12 h.
General Advice
For IV administration, reconstitute with 100 mL of compatible diluent. Shake until suspension is clear; add suspension to 100 mL of appropriate infusion solution. Then add 10 mL of infusion to vial; shake well to ensure that all medication is used and transfer resulting suspension to infusion solution. Color of solution may range from colorless to yellow. Solution is stable for 4 h at room temperature and for 24 h when refrigerated. Do not administer if solution is cloudy.
Do not mix with or physically add to antibiotics. However, it may be administered concomitantly with other antibiotics (eg, aminoglycosides).
Do not use IM preparation for IV administration.
For IM administration, prepare with 1% lidocaine HCl solution (without epinephrine). Prepare 500 mg vial with 2 mL and 750 mg vial with 3 mL of lidocaine. Agitate to form suspension. Color of solution may range from white to light tan. Withdraw and inject entire contents of vial IM. Use within 1 h of preparation.
Storage/Stability
Store unreconstituted powder at or below 77°F.
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Unknown - Tuesday, 26 April 2011
