Description of Atenolol (Tenormin)
A cardioselective beta-adrenergic blocker possessing properties and potency similar to propranolol, but without a negative inotropic effect.
Indications of Atenolol (Tenormin)
Atenolol is primarily indicated in conditions like Angina, Angina pectoris, Cardiac arrhythmia, Early intervention within 12 hrs of myocardial infarction, Hypertension, Myocardial infarction, To prevent recurrence of neural tube defect, and can also be given in adjunctive therapy as an alternative drug of choice in Alcohol withdrawal, Migraine prophylaxis.
Pharmacodynamics
Atenolol, a competitive beta(1)-selective adrenergic antagonist, has the lowest lipid solubility of this drug class. Although it is similar to metoprolol, atenolol differs from pindolol and propranolol in that it does not have intrinsic sympathomimetic properties or membrane-stabilizing activity. Atenolol is used alone or with chlorthalidone in the management of hypertension and edema.
Mechanism of action
Like metoprolol, atenolol competes with sympathomimetic neurotransmitters such as catecholamines for binding at beta(1)-adrenergic receptors in the heart and vascular smooth muscle, inhibiting sympathetic stimulation. This results in a reduction in resting heart rate, cardiac output, systolic and diastolic blood pressure, and reflex orthostatic hypotension. Higher doses of atenolol also competitively block beta(2)-adrenergic responses in the bronchial and vascular smooth muscles.
Half life
6-7 hours
Atenolol (Tenormin)
Dosing (Adults):
Hypertension: Oral: 25-50 mg once daily, may increase to 100 mg/day. Doses >100 mg are unlikely to produce any further benefit.
I.V.: Dosages of 1.25 to 5 mg every 6-12 hours have been used in short-term management of patients unable to take oral tabs.
Angina: Oral: 50 mg once daily; may increase to 100 mg/day. Some patients may require 200 mg/day.
Post MI: I.V.: Early treatment: 5 mg slow I.V. over 5 minutes; may repeat in 10 minutes. If both doses are tolerated, may start oral atenolol 50 mg every 12 hours or 100 mg/day for 6-9 days postmyocardial infarction. Oral: Follow I.V. dose with 100 mg/day or 50 mg twice daily for 6 to 9 days postmyocardial infarction.
A cardioselective beta-adrenergic blocker possessing properties and potency similar to propranolol, but without a negative inotropic effect.
Indications of Atenolol (Tenormin)
Atenolol is primarily indicated in conditions like Angina, Angina pectoris, Cardiac arrhythmia, Early intervention within 12 hrs of myocardial infarction, Hypertension, Myocardial infarction, To prevent recurrence of neural tube defect, and can also be given in adjunctive therapy as an alternative drug of choice in Alcohol withdrawal, Migraine prophylaxis.
Pharmacodynamics
Atenolol, a competitive beta(1)-selective adrenergic antagonist, has the lowest lipid solubility of this drug class. Although it is similar to metoprolol, atenolol differs from pindolol and propranolol in that it does not have intrinsic sympathomimetic properties or membrane-stabilizing activity. Atenolol is used alone or with chlorthalidone in the management of hypertension and edema.
Mechanism of action
Like metoprolol, atenolol competes with sympathomimetic neurotransmitters such as catecholamines for binding at beta(1)-adrenergic receptors in the heart and vascular smooth muscle, inhibiting sympathetic stimulation. This results in a reduction in resting heart rate, cardiac output, systolic and diastolic blood pressure, and reflex orthostatic hypotension. Higher doses of atenolol also competitively block beta(2)-adrenergic responses in the bronchial and vascular smooth muscles.
Half life
6-7 hours
Atenolol (Tenormin)
Dosing (Adults):
Hypertension: Oral: 25-50 mg once daily, may increase to 100 mg/day. Doses >100 mg are unlikely to produce any further benefit.
I.V.: Dosages of 1.25 to 5 mg every 6-12 hours have been used in short-term management of patients unable to take oral tabs.
Angina: Oral: 50 mg once daily; may increase to 100 mg/day. Some patients may require 200 mg/day.
Post MI: I.V.: Early treatment: 5 mg slow I.V. over 5 minutes; may repeat in 10 minutes. If both doses are tolerated, may start oral atenolol 50 mg every 12 hours or 100 mg/day for 6-9 days postmyocardial infarction. Oral: Follow I.V. dose with 100 mg/day or 50 mg twice daily for 6 to 9 days postmyocardial infarction.
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Ditulis oleh:
Unknown - Saturday, 23 April 2011
